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2 edition of Factors influencing morphine toxicity in isolated and aggregated mice found in the catalog.

Factors influencing morphine toxicity in isolated and aggregated mice

John Scott Mohrland

Factors influencing morphine toxicity in isolated and aggregated mice

by John Scott Mohrland

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  • 3 Currently reading

Published .
Written in English

    Subjects:
  • Morphine.

  • Edition Notes

    Statementby John Scott Mohrland.
    The Physical Object
    Paginationix, 96 l. :
    Number of Pages96
    ID Numbers
    Open LibraryOL16753252M

    d) Prolactin.- e) Pineal Gland Hormones.- f) Thyroid Hormones.- 7. Toxicity of Amphetamine.- a) Lethality After Amphetamine Administration.- b) Factors of Importance for Amphetamine Induced Toxicity in Aggregated and Isolated Mice and Rats.- c) Effects of Other Drugs on Amphetarnine-Induced Toxicity in Mice and Rats.- d) Chronic Toxicity of. Twenty-four hour LDSo rhythms for &hetamines were determined in isolated and aggregated mice (Walker, ). In all cases, &hetamine was most toxic during the dark phase of the hr light-dark cycle (on hr, off hr (Table 1). Amphetamine depletes norepinephrine stores, in .

      Describe the action and mechanism of action of Morphine. Assessment 2: Short Answer Test (SAT)/ In class closed book assessment based on the case study of Brian Jones. Weighting: 40%. Word count: words. Content that exceeds the word limit plus 10% will not be marked and consequently will not attract marks. Due Date: Week 5, in registered.   Morphine is a very strong painkiller. It is one of a number of chemicals called opioids or opiates, which were originally derived from the poppy plant and used for pain relief or their calming effects. Morphine overdose occurs when a person intentionally or accidentally takes too much of the medicine. This article is for information only.

    Morphine Sulfate is the sulfate salt of morphine, an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions. In the central nervous and gastrointestinal systems, this agent has widespread effects including analgesia.   Morphometric analysis of the brains of individuals who died of opiate overdose, show that the largest number of dead neurons are those with a small diameter (89). This neuron death is attributed to morphine toxicity of small morphine-sensitive neurons (90). Caspases are intracellular cysteine proteases that induce cell death and inflammation.


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Factors influencing morphine toxicity in isolated and aggregated mice by John Scott Mohrland Download PDF EPUB FB2

Proc West Pharmacol Soc. ; Morphine toxicity in isolated and aggregated mice. Mohrland JS, Craigmill AL. PMID: [PubMed - indexed for MEDLINE]Cited by: 1. Measurements of brain morphine concentrations also failed to demonstrate any differences which could account for the difference in lethality observed in isolated and aggregated mice.

Morphine lethality Aggregation Catecholamines Serotonin LETHALITY from amphetamine administration may be increased markedly if mice are housed in groups (aggregated) rather than housed alone (isolated Cited by: 1.

J Pharm Pharmacol. Nov;23(11) Increased toxicity of morphine-like analgesics in aggregated mice. Davis WM, Brister CC.

PMID:Cited by:   Morphine Tolerance Was Attenuated in Germfree and Pan-Antibiotics Mice. We have previously shown that chronic morphine treatment results in microbial dysbiosis, disruption in gut barrier function, and bacterial translocation, primarily through the μ-opioid receptor (OPRM1) ().To initially establish the role of the gut microbiota in morphine tolerance, germfree (GF) mice and conventionally Cited by: 6.

Morphine was shown to be more lethal to aggregated mice than to isolated mice at an ambient temperature of 29°C but not at 19°C. After morphine administration at 29°C, convulsions were found to be associated with death, and a higher incidence of convulsions was observed in aggregated mice than in isolated by: 7.

Abstract The present study determines the analgesic effects of morphine in grouped and isolated rats and mice. Isolated animals developed altered behavioral patterns, including mouse-killing in rats and mutual aggressiveness in mice.

The analgesic effect of morphine was tested by tail compression in rats and by the hot plate for mice. when combined with morphine and the effect of the combination on the development of tolerance towards morphine.

Mice were administered intraperitoneally with a dose of MG (15 and 25 mg/kg ) combined with morphine (5 mg/kg ) respectively for 9 days. The antinociceptive effect was evaluated by a hot plate test. The protein expression of. In crowded mice, morphine is more toxic at lower DOGGETT, RENO AND SPENCER 7 5 3J .)-Amphetamine TRSO = TRRO r n 1~ 15 40 6 Diprenorphine 6J 5.

4 3~ Pethidine ~-R 5 3 TR50 = TRso 7 Naloxone 7 IsOCarboxazid 5 TR50 6 30& - 2d0 3p0 DOSE (mg/kg) FiG. The effects of morphine (5, 10,and mg/kg SC) on locomotor activity, object manipulation, grooming, rearing, and responsiveness to social stimulation were observed in naive, nontolerant mice.

Morphine induced significant changes in the behavior elements recorded. Factors influencing the action of morphine on acetylcholine release in the guinea-pig intestine. Ambache N. Interaction of drugs and the effect of cooling on the isolated mammalian intestine.

J Physiol. Jan 15; (3)– SCHAUMANN W. Inhibition by morphine of the release of acetylcholine from the intestine of the guinea-pig. The toxicity of d-amphetamine has been related to the stress of aggregation and electric shock [24,65]; morphine aggregation toxicity related to the stress of aggregation and tactile stimulation [18,40]; and digitalis toxicity related to restraint stress [42].

Taken collectively, these data show that drug-environment interactions occur in. The manner in which group housing increases drug toxic- ity is largely speculative.

Mohrland and Craigmill [7] note that convulsions and subsequent death in aggregated morphine-treated mice tested at 29 appear to be induced by stimulation from (i.e., movement by) other mice in the cage.

Babrowski, T. et al. Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine.

• Morphine releases histamine from mast cells, causing urticaria,sweating and vasodilatation• Morphine can cause the bronco-constriction, asthmatics shouldnot receive the drug• Morphine inhibits release of GRH and corticotrophic releasinghormone and it decreases the concentration of luteinizinghormone, FSH & ACTH• It increases prolactin and growth hormone release by.

The dose-response relationship for hyperactivity in grouped mice following the injection of morphine sulphate has been established. The activation response can be modified by drugs which affect either catecholamines or indoleamines.

Morphine-induced antinociception was evaluated by measuring response latencies in the hot-plate test. We used a dose of morphine (10 mg/kg body weight) and route of administration (subcutaneous) that are known to induce analgesia in many strains of mice ().The analgesic effect of morphine was significantly potentiated and prolonged in the knockout mice relative to their wild-type littermates ().

Purchase Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 - 1st Edition. Print Book & E-Book. ISBN1. J Pharmacol Exp Ther. Nov;(1) Factors influencing the incidence of reversible lens opacities in solitary and aggregated mice.

a positive influence on the endocrine, morphine-induced toxicity in aggreg ated. mice. amphetamine toxicity in mice, and produced hypothermia in mice.

It also. Influence of previous housing history on the toxicity of amphetamine in aggregate mice. studied in isolated and aggregated mice with and without previous habituation to the physical or to the.

• Major factors influencing a drug [s C footprint: –Solvents • Morphine washed and filtered • Sulphuric acid added • Morphine sulphate crystallised, filtered, dried and –Toxicity –Water use.

Resultsg CO 2 1. Morphine production to the factory gate – 24g CO 2.The two metabolites of morphine, morphineglucuronide (M3G) and morphineglucuronide (M6G), have been studied intensively in animals and humans during the past 30 years in order to elucidate their precise action and possible contribution to the desired effects and side effects seen after morphine administration.

M3G and M6G are formed by morphine glucuronidation, mainly in the liver, and.Morphine is an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. Morphine binds to and activates specific opiate receptors (delta, mu and kappa), each of which are involved in controlling different brain functions.